Built in 1904 for Dr. George Frederick Shrady (the former physician for General Ulysses S. Grant) and his wife Hester, this 20-room Italian Renaissance-style cottage was later purchased in 1925 by Walter B. James, the President of the Jekyll Island Club, who named it “Cherokee.” The house is also known as the Shrady-James House. Renovated in 2001, it now serves as a hotel.