The Cairo School served the Cairo Community of Sumner County, Tennessee, for thirty-five years. Opened in 1923, it was built using the one-room/one-teacher Rosenwald school plan. Students attended the school up to eighth grade.

The community raised $700 for the school’s construction, while the Rosenwald fund provided $500. The Tennessee public school fund matched the community’s contribution and gave $700.

It was one of seven schools built in the county. It is one of two extant schools in the community, and both are listed on the National Register of Historic Places.