Mulberry AME Church was organized in 1871. Like many churches in the South, the congregation began meeting in a brush arbor, a shelter constructed with poles covered in tree limbs and hay. It was named after a mulberry tree near the church.

A log structure was completed in 1872. Another building was built in 1878 and used until 1918 when it was lost to fire. The current Carpenter Gothic church was completed in 1919. Mulberry is the mother church to the St. Paul, St. Peter, and Shady Grove AME churches in Abbeville County.