The Dean Street School was built in the 1890s in the heart of the middle-class Black neighborhood that developed around Dean Street. Originally a white wooden school, the brick was added to the facade in the 1930s.

The school was named the Alexander School after the long-serving principal, R. M. Alexander, who was in that role from 1895 to 1929. It served as the school for Black schoolchildren until the 1960s when Spartanburg schools finally began integrating.

In 1990, the Epsilon Nu chapter of the Omega Psi Phi fraternity purchased the building. They restored the school, and it is now their local fraternity headquarters.