Shiloh Missionary Baptist Church and School were founded in 1916 and 1922, respectively. The school is the only Rosenwald school that is still standing in Macon County, Alabama.

The church and school were one of the locations during the Tuskegee Syphilis Study where participants were told to meet so the United States Public Health Service officials could pick them up for treatment or lack thereof.

The church and school were placed on the National Register of Historic Places in 2010. The school went under restoration in 2011.